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(Senior / Principal) Scientist Protein Engineering (职位编号:92585926)

面议

上海市博士及以上2年及以上

发布时间:2023-09-06

职位描述

POSITION
At Roche, over 90,000 colleagues are working together and doing what patients need next. Our ambition is to deliver novel therapeutics, diagnostic solutions and insights to patients with game changing clinical benefits. Roche Innovation Center Shanghai is seeking multiple talented and experienced Senior Scientists or Principal Scientists for the discovery, design and engineering of novel antibody drugs. The final position offered depends the experience level of the candidate. The position requires the candidate to perform the engineering of antibodies through rational design, computational engineering or display technology. The successful candidate will work with dynamic and highly motivated teams to drive the development of antibody therapeutics for unmet medical needs. The candidate will collaborate with colleagues in Antibody discovery, Immunology, Oncology, Protein Sciences, Structural Biology, CADD, Pharmaceutical Sciences, and CMC. This position requires effective participation in multidisciplinary teams with members from RICS.
RESPONSIBILITIES
Potentially act as AD project lead and collaborate with other cross-functional project leads in the design and execution of the program strategies and goals.
Perform protein engineering to drive therapeutic antibody lead selection, design, and optimization for antibody discovery projects.
Design and execute synthetic phage libraries for antibody optimization.
Design and select fit for purpose antibody format.
Develop cutting-edge computational tools in protein engineering.
Coordinate with CROs and monitor outsourcing activities to ensure timely delivery of qualified data to steer portfolios.
Participate in due diligence to evaluate relevant external opportunities in order to license in assets or technologies.
CANDIDATE PROFILE
Qualification and experience
The candidate qualifications include a Ph.D. in a biological science, including at least 5 years of recent structural biology, computational biology/chemistry, protein engineering, preferably in a biotechnology or pharma setting. A track record of effective protein engineering support of antibody generation and optimization efforts in drug discovery programs.
Competencies
The ideal candidate will have demonstrated competence in the following areas:
Strong background in structure-based protein analysis and engineering. Experience with computational protein engineering, antibody paratope-epitope modeling, protein engineering to reduce immunogenicity, and next-generation sequencing (NGS) are vital.
Deep understanding of display technologies and workflows.
Expertise of cutting-edge biologics formats including bi- and multi-specific antibodies.
Molecular biology skills and cell biology assay experience is a plus.
Experience with cloud or high-performance computing (e.g. AWS, GCP) and AI/ML to model sequence and biological data is highly preferred.
Solid record of accomplishments and publications as evidence of scientific knowledge. The proven ability to learn new techniques, to problem solve, and to have a sustained record of productivity.
Excellent communication and leadership skills with a deep commitment to working as part of teams and recognizing the strengths of everyone on the team.

其他要求

  • 3人

公司介绍

上海罗氏制药有限公司成立于1994年,是抗肿瘤、抗**、移植等关键领域的市场领导者。在大型跨国药企中,我们率先在中国建成了包括研究、开发、生产、营销等环节在内的完整的医药价值产业链。罗氏中国正向着成为罗氏全球第三个战略中心的目标迈进,以实际行动践行在中国长期发展的承诺。

我们始终以患者为中心,致力于帮助患者从根本上延长生命和改善生活质量。目前,罗氏在华拥有16个产品,覆盖8个治疗领域。我们与**、医疗机构以及非**组织等社会各界多方携手,共同探索创新的合作模式,通过一系列有影响力和可持续的举措惠及更多的中国患者。

更多罗氏中国信息,请登陆罗氏中国网站 ****************

上海罗氏制药有限公司上海总部

行业:
制药.生物
规模:
1-49人
性质:
其他
地址:
上海浦东龙东大道1100号(邮编:201203)

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